Abstract: Karst collapse column is widely developed in north China coal field, which is a serious defect of coal measure strata and has caused many serious water inrush disasters. It is of practical significance to study the characteristics of water conduction and grouting mechanism of collapse column for ensuring the safe mining of coal resources. According to the characteristics of collapse column water channel, the structure form of collapse column and the characteristics of exploration borehole water, combined with typical investigation and treatment cases of sink column, on the basis of the traditional mode of loose gap water conduction and micro-pore fracture infiltration water conduction, a new mode of vein fracture water conduction of collapse column is summarized and proposed, and the form of water damage caused by such collapse column is given. It is found that the column body of this kind of collapse column is generally dense and distributed by the combination of hard and soft gravel, but the distribution is not uniform. The gap of the broken rock is not filled by the crushed mud, sand and mineral crystallization, and there are irregular flat fissure or approximately round hole concentrated water channels. The primary analysis shows that the main reason for the formation of such collapsed columns is the difference of porous flow and crystallization caused by the inhomogeneity of the columns. The transparent and visual grouting model test of the vein fissure water-guiding collapse column was carried out, and the treatment process of single-hole high-pressure grouting on multiple water guiding channels was visually observed. Combined with relevant theories, the high-pressure grouting mechanism of the vein fissure water-guiding collapse column involving the composite forms of porous grouting, split grouting and fissure squeezing and sealing was proposed. In order to realize the comprehensive control of the single grouting hole on the water channel of multiple vein cracks. The research results have been applied to the grouting treatment of 9–6 water-guiding collapse column in Hemei nine Mine, which is buried more than 600 m, has a water pressure of 7.67 MPa and a plane area of 5 200 m². According to relevant standards, the span of grouting control section is designed, and the water conductivity characteristics of the vein fracture of the collapse column can be characterized by the exposure of the roadway and the water discharge from the drilling. The design adopts the matching holes, layered holes and segmentation grouting to achieve full coverage of the grouting area, and the analysis of the grouting pressure response curve can indicate the process of seepage, splitting and compaction of the slurry. The treatment effect of the subsidence column is evaluated comprehensively through the grouting situation, geophysical exploration, microseismic monitoring and waterflood test analysis. The working face affected by the subsidence column has been safely mined. The research results provide theoretical and technical support for the treatment of the vein fracture water-conducting collapse column.