Abstract: There is a risk of coal spontaneous combustion during coal mining and storage, which may cause accidents such as CO (carbon monoxide) poisoning. Coal oxidation rate is an important factor affecting the process of coal spontaneous combustion, while ambient oxygen volume fraction and temperature are key parameters affecting coal oxidation rate and CO generation rate. In order to explore the intrinsic relationship between coal oxygen consumption rate (\phi ), CO generation rate(\varphi ), ambient oxygen volume fraction and temperature, a closed oxygen consumption experiment is carried out with Hongqingliang coal samples as the research object. By controlling the temperature in the range of 20～70 ℃ (the latent period of coal spontaneous combustion), the curves of oxygen volume fraction (c) and CO volume fraction (g) changing with time are synchronously monitored and recorded. The correction method for oxygen consumption coefficient (\lambda _\mathrmc) and CO generation coefficient (\lambda _\mathrmc\left( \mathrmCO \right) ) of different air/coal volume ratios caused by experimental conditions is proposed; and the binary function relationship between oxygen consumption rate (\phi ) and CO generation rate (\varphi ) of coal under different oxygen volume fractions and temperature conditions is derived through regression analysis. The results show that: the oxygen consumption coefficient (\lambda _\mathrmc), CO generation coefficient (\lambda _\mathrmc\left( \mathrmCO \right) ), critical oxygen volume fraction of oxygen consumption (\varepsilon _\mathrmb), and CO limit volume fraction (\varepsilon _\mathrmb\left( \mathrmCO \right) ) in the equation are all functions of temperature. When the temperature rises from 20 °C to 70 °C, the oxygen consumption coefficient (\lambda _\mathrmc) and the CO generation coefficient (\lambda _\mathrmc\left( \mathrmCO \right) ) show an exponential change pattern with the increase of temperature; the critical oxygen volume fraction of oxygen consumption (\varepsilon _\mathrmb) shows a linear downward trend; and the CO limit volume fraction (\varepsilon _\mathrmb\left( \mathrmCO \right) ) shows a linear upward trend. Finally, based on the experimental data and analysis results, the function model for the oxygen consumption rate (\phi ) and the CO generation rate (\varphi ) is established, with oxygen volume fraction and temperature as variables. The research results further enrich the theory of coal spontaneous combustion, which can provide theoretical guidance for numerical simulations related to coal spontaneous combustion; this provides also scientific evidence for fire prevention and control in coal mines.