Abstract: As the mining depth of coal mines increases, the surrounding rock temperature at the excavation face rises continuously, significantly increasing the cooling demand in deep mines and hindering the sustainable development of deep resources. To address the high energy consumption issue of traditional cooling and dehumidification technologies in hot water geothermal anomaly type heat damage mine, this paper proposes a single-rotor multi-zone desiccant wheel cooling and dehumidification system for excavation face in hot water geothermal anomaly type heat-harm mine. In this study, based on the enthalpy difference method, energy balance relationships were established for the excavation face and the cooling system, and the cooling capacity calculation formula for the excavation face was derived. Additionally, a thermodynamic model of the single-rotor multi-zone desiccant wheel cooling and dehumidification system suitable for deep mine excavation face was constructed, and the effects of various operating parameters—including rotor zones, rotor speed, air flow parameters, regeneration temperature, and chilled water supply temperature—on the performance of the cooling system were analyzed. Comparison with rotary wheels of different zone configurations showed the thermal coefficient of performance (TCOP) of the wheel with a processing/purge/regeneration zone area ratio of 1∶1∶2 was 45% higher than the non-zoned counterpart. Simulation results indicated that higher rotational speed reduced dehumidification capacity and increased required cooling load; elevated regeneration temperature improved dehumidification capacity but decreased TCOP; lower surface air cooler supply water temperature enhanced both dehumidification capacity and TCOP. Optimal system operating conditions were determined as: rotary wheel speed 12 r/h, regeneration temperature 85℃, surface air cooler supply/return water temperature 7/12 ℃. Under these conditions, the system achieved dehumidification capacity 124.43 kg/s, refrigerating capacity 423.93 kW, regeneration energy consumption 348.48 kW, and TCOP 1.22. Additionally, under extreme high-temperature and high-humidity conditions, the system exhibited a maximum TCOP of 1.15, with both dehumidification and refrigerating capacities meeting requirements.