Abstract: To improve the economic safety of open-pit mining operations,save mining costs to the greatest extent, improve mining efficiency, and comprehensively enhance the timeliness of landslide pre-slip early warning monitoring,research background is the deep mining of Nanfen open pit iron mine with multiple occurrences of giant sliding bodies, and exploring the unique slope damage patterns of open-pit iron mines through research on the stability analysis and monitoring status of high and steep slopes in domestic and foreign,combined with the successful application of Newton force imminent slip intelligent warning technology in Nanfen landslide early warning, the feasibility of the Newton force imminent slip monitoring is systematically expounded.In view of the phenomenon of a large number of unstable or potentially deformed areas in the footwall of high and steep slope in Nanfen iron Mine, based on the summary of three damage modes of the current slope, the key footwall areas are analyzed based on the MSARMA, GEO-SLOPE and Swedge numerical calculation software, combined with the Newton’s force change law of geological body disaster by Academician He Manchao, innovatively proposes a trinity prevention and control technology of intelligent monitoring early warning for slope stability “NPR Newton’s force landslide monitoring as the main body, long-term threshold monitoring, short-term pre-slip early warning and post-deformation field survey”, it has been applied in the prediction of the collapse of giant sliding bodies on the 574 and 502 platforms.The field slip warning shows that NPR prestressed anchor cable enhances the stability of slope, improves the real-time performance of monitoring system, effectively verifies the reasonable accuracy of intelligent slip warning technology of trinity slope stability, and puts forward reasonable and effective emergency control measures for the safe and sustainable mining of open-pit mine.