Abstract: According to the negative pressure too high existed in the main ventilator of Mine East Ventilation Shaft in No.8 Mine of Pingmei, a barometer base point method was applied to the ventilation resistance measurement of the ventilation system.The measured results showed that the total resistance of mine ventilation in Mi ne East Ventilation Shaft was 3 077 Pa, over 2 940 Pa stipulated in Coal Mine Ventilation Technical Condition.The ventilation resistances at the air income section and t he air retuning section were too high.The main causes were the ventilation route too long, some gateway cross section too small, ventilation distribution irrational.In Co mbination with the long term mining plan, an optimized plan of the ventilation system in the Mine East Ventilation Shaft was provided.The MVSS software was applied to the ventilation network calculation of the optimized plan.With the comprehensive comparison, No.2 plan was finally applied to the optimization of the ventilation system i n Mine East Ventilation Shaft.