Abstract: According to the poor seam stability, complicated geological structure, many outburst mines, the gas disaster serous actual problems in Huaibei Coal Mi ning Area, the paper provided that gas comprehensive prevention and control system should be established from the aspects of the idea, management, technology, inve stment, training and others.The prevention and control system should be implemented and should be continuously innovated and improved .After the gas comprehensive prevention and control system implemented, the mine gas drainage rate in Huaibei Coal mining Group was over 48% and the number of the gas content over limit was h ighly reduced.From 2004 to 2010, the gas uillization quantity was increased from 7.65 million m3 to 46.00 million m3, the anual raw coal production was increased fro m 21.51 million ton to 32.00 million ton and the fatal rate per million ton was reduced from 0.7 to 0.18.