Abstract: In order to study the CO emission law of the fully-mechanized coal mining face,to guide the ventilation of the coal mining face and to solve the spontaneous combustion prevention and control of the goaf,based on No. 014N1-1 fully-mechanized top coal caving mining face in the first mining seam-No. 1 seam of Rui’an Mine as a prototype,COMSOL Multiphysics 5.0 was applied to establish a CO numerical model of the goaf. And an orthogonal experimental design and a numerical simulation calculation were conducted. Then the SPSS software was applied to the stepwise regression of the simulation results. A regression model of the CO emission volume with five factors of the CO sources intensity,CH4 source intensity,CO reaction velocity,pushing forward speed and air velocity and the site measured data were applied to correct the CO emission. The results showed that,there was an ultra obvious correlation between the CO emission volume and the five factors. The predicted results of the corrected CO emission volume could have a high fitting with the site measured data. The model could be applied to predict the CO emission from the goaf and favorable to guide the site practice work of the mine ventilation and the fire prevention and control.