Abstract: Large-scale underground mining will cause the overburden to move,deform and even destroy,and form a large-scale subsidence area on the surface. Th e subsidence area is a bad ground, and there is the possibility of subsidence and deformation. Therefore,large buildings on the subsidence area has a large potential sa fety hazard. Understanding the interaction mechanism between buildings and ground is the prerequisite for ensuring the safety of the buildings. Taking the large buildin gs structure as the research object,using the numerical simulation software such as Matlab and COMSOL,the numerical model of the superstructure-foundation-ground i nteraction was established. The continuous damage evolution theory was used to analyze the mining response of various structures such as the superstructure and fou ndation of large buildings under the action of the ground inclination,horizontal tension,horizontal compression,negative curvature and positive curvature.the effects of gr ound inclination and curvature deformation on the deformation of the superstructure and foundation of the building are all integrated,and the displacement of the buildin g is small in the middle and large on both sides; the horizontal deformation of the ground has a greater impact on the deformation of the building foundation,and the def ormation of the superstructure is relatively affected smaller. The additional stress on the building caused by ground mining deformation is mostly concentrated at the no des of the rod structure,especially under the horizontal deformation and curvature deformation of the ground,the additional stress is mainly concentrated on the part of t he rod structure of the foundation. The curvature deformation and horizontal deformation of the ground have greater damage to the building,and the inclination deformat ion has less damage to the building; The deformation of the superstructure is significantly smaller than that of the foundation part,and the deformation of the region with a large overall stiffness is significantly smaller than the region with a small stiffness. The research results will provide theoretical guidance for the safety design and pro tection of large buildings built above the subsidence area.