Abstract: According to seam thickness would be the high accurate data obtained from the mine drilling exploration, the paper had a study on the seam thickness d ata of the drilling applied to the prediction of the seam thickness distribution and the tectonic prediction. With a mining block in the south wing at -690 m Level of Kailua n Donghuantuo Mine as the study block, the paper stressed the analysis on different conditions of the seam thickness data missing. Based on the no zero value and zer 0 value seam thickness data from the drilling individually, the Surfer software was applied to draw the thickness value lines of No. 5 seam, No. 7 seam and No. 8 seam. The paper had a comparison analysis on the spatial features of the seam thicknesses and had an inference on the tectonic location and others to cause the seam missi ng. The results showed that the seam thickness missing from drilling would be general. There would be the depositional lapout, tectonic faulted, weathering denudation and insufficient drilling depth to cause the missing. The first two conditions would be the seam thickness was zero value. When the zero value was not considered or th e zero value was considered, the distribution scope of the unmineable block with seam thickness less than 0.6 m would be a big difference. In the area of the drilling rig 102/vehicle 10- Dongguan 22- vehicle 32- -vehicle 106- -vehicle 105- -vehicle 14, there were many boreholes' seam thickness tectonic missing and there would be faul t tectonic zone in NW direction.