Abstract: In order to solve the problems of water resources shortage in the production process existing in the large-scale coal mine base of China's west and the p roblems of zero liquid discharge of mine drainage water with high mineralization, the technology system including purifying treatment, advanced treatment, concentrate d treatment and evaporation crystallization treatment was researched and applied. The results showed that the technology system for mine drainage water with mass co ncentration of total dissolved sdids ( TDS)≤5 000 mg/L had advantages by using coagulation, purification and filtration for purifying treatment, using brackish water rev erse osmosis ( BWRO) for advanced treatment, using BWRO with disk tube reverse osmosis ( DTRO) for concentrated treatment, and using multiple effect distillation ( MED) for evaporation crystallization treatment. Adopted the technology above to treat mine drainage water with TDS mass concentration 1900 ~ 2 400 mg/L, the water quality could be achieved TDS mass concentration z90 000 mg/L of high-concentrated saline water, system water recovery z96.5% of whole systems and TDS mass CO ncentration S300 mg/L of last effluent. Sodium chloride and sodium sulfate separated from evaporation crystallization could be met the standards of industry salt, and C ould be used as raw materials for chemical industry. The whole technology system with 7.89 RMB/t of integrated operating cost had advantages of stable operation, go od tolerability for change of water quality and satisfying treatment effects.