Abstract: According to the status of structural coal development and serious gas hazard in Pingdingshan Mining Area, in order to study the applicability of separate-layer pressure control and multi-layer drainage technology in the Shoushan No.1 Coal Mine of Pingdingshan Mining Area, the effect of gas production and influence factors of separate-layer pressure control and multi-layer drainage for No.4-2 and No.2-1 coal seam have been analyzed, and the reason of poor gas production of separate-layer pressure control and multi-layer drainage for No.4-2 and No.2-1 coal seams is discussed. The result indicates that the pressure,pressure gradient,permeability,properties of the roof with backplane and hydrogeological conditions are similar, and this has not influenced the multi-layer draining effect; the larger coal seam spacing, the smaller critical desorption pressure of No.2-1 coal seams and the soft structure of No.4-2 coal seams have seriously influenced on the multi-layer draining effect and cause poor gas production. So the technology of separate-layer pressure control and multi-layer drainage is not suitable for No.4-2 and No.2-1 coal seams of Shoushan No.1 Coal Mine.