Abstract: In order to the scientific layout of the coal bed methane wells and to ensure the rational and full development of the coal bed methane resources, based on comprehensive analysis on the seam geological conditions in Panzhuang Area, a square area of 1 000 mx1 000 m, taking QN-3 Mine Shaft in the east as a center p art of the block was selected as the simulation region.The target seam of the simulation was No.3 seam.The COMET3 software was applied to correct the basic data wit h the historical ftting.Based on the different well numbers (4 ~ 6 wells)，4 different well network alternatives were designed and the numerical simulation and prediction on the production capacity was conducted for each alternative.The results showed that the optimized space between the wells in the region would be about 500 m, the optimum well layout alternative would be a square with a center and a pentagon with a center. The center well could highly improve the production.