Abstract: According to the technical problems that hydrodynamic large channel water inrush disaster control can’t construct straight hole in the ground. Taking a large inrush disaster controlling engineering from Paner coal mine as an example, based on the analyses of hydrogeology condition of water inrush, the controlling project to carry out blocking source and closure simultaneously by directional branch oblique hole is presented.According to the past experience of water plugging by straight hole, hydraulic jet aggregate perfusion process and high pressure grouting process are established, and key technology of aggregate perfusion and ending high pressure grouting standard are given. According to the characteristics of drilling and grouting, the conductor morphological characteristics are speculated combined with the basic condition of collapse column development in Huainan mining area. The results of grouting water plugging indicate that the residual inflow of the water inrush point is zero and the Ordovician limestone water level gets good recovery. It means the water plugging rate is 100%. The unit water absorption of branch holes of blocking source all are less than 0.1 Lu, which means blocking source gets good effect and the water connection between the Ordovician limestone water and the water inrush point is cut off completely.