Abstract: To solve the problem of ground subsidence and building failure induced by large-scale water drainage in a loose alluvium in the Zhuxianzhuang Mine, a calculation model was built to obtain the strata compression and ground inclination caused by each layer based on long-term measurement data in the neighboring Xinglongzhuang Mine, and the subsidence and inclination of the shafts and typical buildings in the drainage-influenced area were predicted and evaluated. Results showed that the compression rate of the gravel and coarse sand was the highest in the loose alluvium in the Zhuxianzhuang Mine, which was 0.174 8 mm/m2, while the compression rate of the clay was the lowest, which was 0.051 7 mm/m2. The maximum and minimum subsidence of the typical buildings and structures in the studied area was 532.75 and 237.04 mm, respectively. The maximum ground inclination was 0.120 mm/m, which was lower than the value required in the Grade Ⅰ damage of buildings and structures. Considering the stability of the buildings and structures and the stagnant surface water, technical measures for failure prevention of the buildings and structures were proposed, which included controlling drainage drawdown and drainage rate, relocating or draining buildings and structures, backfilling highways, and investigating the positional relationship of the shaft wall and the equipment.