Abstract: According to the high operation loading and other problems of the mine main ventilator caused by the high ventilation resistance, the irrational ventilation resistance distributions in the air income section, ventilation section and air returning section existed in the mine ventilation system of Yuyang Mine, the ventilation netw ork calculation software was applied to the calculation and optimization of the mine ventilation network and to the natural distribution of the ventilation in the mine ventil ation network and the distribution calculation depending on the requirements.The calculation results showed that the ventilation calculation software could have the em ulation dynamic simulation of the ventilation network calculation, the ftting of the ventilator features and the ventilation adjustment function of the local ventilation syste m.The application of the ventilation network calculation software could make the qualitative analysis ventilation system upgraded to a digitalized and accurately analysis ventilation system and thus the ventilation system could be schedule and target adjusted.