Abstract: With the collection and analysis on the outburst parameters and the previous coal and gas outburst accidents occurred in the 74 mines and 107 seams i n Guizhou Province, a study on the outburst seam and outburst index distribution features in Guizhou was conducted. According to the coal and gas outburst features a nd the main problems existed in the outburst prevention works in Guizhou, the relative outburst prevention measures were provided.Taking the regional outburst prevent ion as the key, the optimization of the mine mining and excavation layout, the enlarged input of the mine outburst prevention equipment, the enhanced mine gas parame ter measurement and the study on the outburst prevention technology, the enhanced outburst prevention knowledge training and the improvement of the staff quality Co uld be applied to reduce the coal and gas outburst accidents occurred in Guizhou mine.