Abstract: According to the typical hydrogeological conditions of Huayingshan Mine, the paper systematically analyzed and summarized the karst structure channel s, the fractural structural channels, the mining crack channels, poor sealed boreholes and the goaf affected to the threatening degree of the mine water inrush.Accordin g to the threatening degree and the scope of the mine water disaster in the mining area, the water inrush threatening coefficient was applied to divide the mining area to a non water inrush threatening region, a less water inrush threatening region, a medium water inrush threatening region, medium strong water inrush region and strong water inrush region.The paper provided the related measures and proposals on the regional mine water prevention and control.According to the multi water disaster sou rces and high threatening features of Huanyingshan Mining Area, a comprehensive water prevention and control technical measures and system was established with a n integration of "monitoring and measuring prediction, prevention and exploration combination, control and detection, and comprehensive prevention.