Abstract: To achive large-scale explot mulit ell expoitaton :an impove colbed metiane productio by enlarging the pressure dop are athouh iter-wellintererene and invreasig desopion oume T aking Hfantheng Block a the experimentaton area,numercal simudaion was used osudy the pressure popagaton thrcter nder th condtionofmuft ull eploltaton diferent taes And comtined itithe pourtindaof he experimentaton re the pager alzed the production chrcerstos o coabed metianewlls or the coresponding sages The resls showed that the pressure ransmisson hasthre stages Aitr poducion one year ressue ransmis inependantly sice te iner ell teferene does t fom Afer productionto yeas sme well il orm inter-wel lintererence with water dranage and gas poduction an at th same imepessur isadphenomenon chactersicoud apear tecuse of the ema emenof rservoir pressure unbalance. After production six years,well group could form a whole inter-well interference.