Abstract: In order to effectively control harmful gas concentration in mine refuge chamber and to ensure the safety of refuge personnel,thepaper analyzed harmful ga s type and the releasing rate occurred from the metabolism of human body during the refuge process. In combina-tion with tolerance capacity of a human body in the harmf ul gas environment,the paper proposed that CO、H2S、 NH3、CH4and other harm-ful gas occurred from the metabolism of human body would not be necessary to be purifi ed with the purification measures. A theoreticalanalysis showed that when an average air supply volume per man was 107 L/ min,the CO2 average volume fraction of the C hamber shouldbe controlled at 0.5% and thus the requirement of the CO2 purification in the chamber could be met. An average ventilation supply volumeof 450 L/ min per man could meet the requirement of the CO rapid purification stipulated in theConstruction and Management Provisional Regulations of Emergent Refuge System in Underg round Coal Mine. In combination with a tolerance capacity of a human body in a CO con-centration environment,the paper proposed that the CO rapid purification time in th e chamber could be expanded. The experiments showedthat two sets of a purification devices with the air supply of 4.7 m3/ min and effective purification power of 20% ~ 30% could meet air pur-ification requirements of chamber with 50 persons.