Abstract: Aiming at the problems of zero discharge treatment technology of mine water with high salinity，the zero discharge treatment tech- nology of mine water with high salinity was researched from pretreatment，advanced treatment，concentration treatment and evaporation and crystallization．The results show that the engineering application of high mineralized mine water pretreatment and deep treatment is exten- sive，and technology is very mature．However，the engineering application of concentration treatment and evaporation crystallization process is less，and the key technologies still need to be improved．Through comparison and selection，combined with typical case analysis，the paper puts forward the optimization process of“lime+combination of softening of sodium carbonate and clarification( or coagulant and sedimenta- tion) +filtration+ultrafiltration+softening of ion exchange resin+high performance reverse osmosis+decarbonize+nanofiltration+concentration by ED+multiple effect distillation( MED) crystallization ”．The produced water of nanofiltration is partially reused for regeneration of sof- tened resin after ED concentration，so as to realize waste treatment by waste．