Abstract: In order to further improve the effectiveness of the regional treatment technology for Karst water damage, reduce the risk of water inrush on the floor, and solve safety technical issues such as the choice of treatment level, treatment model, and safety governance range during the regional governance process, based on the practice of the energy-damaged regional water pollution treatment project for many years in Jizhong Energy Group, through in-depth analysis of the water treatment cases at the working face in recent years in the Hanxing mining area, the basic principles for the selection of the treatment level of the limestone water area were proposed; A new model for comprehensive management of multi-level "three-dimensional" area of Karst water damage on the floor combined with ground bedding treatment and underground penetration treatment was presented. The calculation method of the safety treatment range of working face under several different structural conditions was given. In addition, it has been applied in the treatment of water hazards in the extremely complex hydrogeological conditions of No.182602 Wutongzhuang coal mine in Fengfeng mining area, and has achieved good control results. It has a good reference for the regional treatment of floor karst water damage under similar conditions.