Abstract: In order to predict the favorable zone for exploration and exploitation of coal measure gas,based on the theory of the fuzzy mathematics, the study had a systematic analysis on the formation condition, reservoir condition, gas bearing condition and geological condition as well as other factors affected to the coal measure gas and a prediction evaluation system of the coal measure gas favorable zone in Eastern Henan Area was established. In combination with the calculation method of the fuzzy mathematics, the relevant comprehensive evaluation coefficients were finally obtained. The results showed that the most favorable blocks of the coal measure gas on Eastern Henan Area as the preliminarily predicted would be Block ⅱ1 and ⅳ1,and the comprehensive evaluation coefficients were 0.808 and 0.788 individually. The good gas bearing and reservoir conditions of the two blocks would be more favorable to the exploration and exploitation of the coal measure gas.